PS1/APP Characterization

Holcomb L., Gordon M., McGowan E., Yu X., Benkovic S., Jantzen P., Wright K., Saad I., Mueller R., Morgan D., Sanders S., Zehr C., O'Campo K., Hardy J., Prada C., Eckman C., Younkin S., Hsiao K., Duff K. (1998) Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nature. Med, 4: 97-100

Wengenack B., Whelan S., Curran G.L., Duff K. and Poduslo J.F. (2000) Quantitative Histological Analysis of Alzheimer's Amyloid Deposition in APP, PS1 Transgenic Mouse. Neuroscience, 101(4): 939-944

McGowan E., Sanders S., Iwatsubo T., Takeuchi A., Saido T., Zehr C., Yu X., Uljon, S.E., Wang R., Mann D., Dickson D., Duff K. (1999) Amyloid phenotype characterization of transgenic mice over-expressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes. Neurobiol. Dis., 6 (4), 231-244

Poduslo J.F., Curran G.L., Wengenack T.M., Malester B. & Duff K. (2001). Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease. Neurobiol. Dis., 8: 555-567

Cognitive Decline

Holcomb L.A., Gordon M.N., Jantzen P., Hsiao K., Duff K. & Morgan D. (1999). Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits. Behav. Genet., 29(3): 177-185

Arendash W.A., King D.L., Gordon M.N., Morgan D., Hatcher J.M., Hope C.E. & Diamond D.M. (2001). Progressive, age-related behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes. Brain Res., 891: 42-53.

Gordon M.N., King D.L., Diamond D.M., Jantzen P.T., Boyett K.V., Hope C.E., Hatcher J.M., DiCarlo G., Gottschall W.P.E., Morgan D. & Arendash G.W. (2001). Correlation between cognitive deficits and Ab deposits in transgenic APP+PS1 mice. Neurobiology of Aging, 22: 377-386.

Degeneration

Le R., Cruz L., Urbanc B., Hsiao-Ashe K., Duff K., Irizarry M.C., Stanley H.E. & Hyman B.T. (2001). Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer's disease: implications for neural system disruption. J. Neuropathol. Exp. Neurol., 60(8): 753-758

Hernandez D., Sugaya K., Qu T., McGowan E., Duff K. & McKinney M. (2001). Survival and plasticity of basal forebrain cholinergic systems in mice transgenic for presenilin-1 and amyloid precursor protein mutant genes. Molecular Neuroscience, 12(7): 1377-1384

Takeuchi A., Irizarry M.C., Duff K., Saido T.C., Hsiao Ashe K., Hasegawa M., Mann D.M.A., Hyman B.T. & Iwatsubo T. (2000) Age-related amyloid _ deposition in transgenic mice overexpressing both Alzheimer mutant Presenilin 1 and Amyloid _ precursor Protein Swedish mutant is not associated with global neuronal loss. Am. J. Pathol., 157(1): 331-339

Wong T.P., Debeir T., Duff K. & Cuello A.C. (1999) Reorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic mice carrying mutated presenilin-1 and amyloid precursor protein transgenes. J. Neurosci., 1, 19 (7): 2706-2716.

Kurt M.A., Davies D.C., Kidd M., Duff K., Rolph S.C., Jennings K.H. & Howlett D.R. (2001) Neurodegenerative changes associated with beta-amyloid deposition in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes. Exp. Neurol., 171: 59-71

Inflammation

Matsuoka Y., Picciano M., Malester B., LaFrancois J., Zehr C., Daeschner J.M., Olschowka J.A., Fonseca M.I., O'Banion M.K., Tenner A.J., Lemere C.A., Duff K. (2001) Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease. Am. J. Pathol., 158(4): 1345-1354

Amyloid modulating agents

Refolo L., Pappolla M., Malester B., LaFrancois J., Wang R., Tint G., Sambamurti K., Bryant-Thomas T. and Duff. K. (2000) Hypercholesterolemia accelerates amyloid pathology in a transgenic mouse model for Alzheimer's disease amyloidosis. Neurobiol. Dis., 7(4): 321-331

Morgan D., Diamond D., Gottschall P., Ugen K., Dickey C., Hardy J., Duff K., Jantzen P., DiCarlo G., Wilcock D., Connor K., Hatcher J., Hope C., Gordon M. and Arendash G. (2000). A_ Peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature, 408: 982-985

Refolo L. M., Pappolla M. A., LaFrancois J., Malester B., Schmidt S. D., Thomas-Bryant T., Tint G. S., Wang R., Mercken M., Petanceska S.S. & Duff K.E. (2001). A Cholesterol-lowering drug reduces b-Amyloid pathology in a transgenic mouse model of Alzheimer's disease. Neurobiol. Dis., 8: 890Ð899

Campbell-Switzer Silver Staining for Alzheimer's Disease

Rosenwald A. et al. (1993) Comparison of silver stainings and immunohistology for the detection of neurofibrillary tangles and extracellular cerebral amyloid in paraffin sections. Acta Neuropathol. (Berl. ); 86: 182-186

Cullen K.M. et al. (1996) Improved selectivity and sensitivity in the visualization of neurofibrillary tangles, plaques and neuropil threads. Neurodegeneration, 5: 177-187

Rickert C.H. et al. (1997) Three-dimensional reconstruction of senile plaques in Alzheimer's disease. J. Microsc., 186: 263-269